HUNTINGTON BEACH, Calif. — May 5, 2026 — Leonhardt Ventures LLC announced today a new provisional patent application covering systems and methods for bioelectric modulation of the FOXO3, AMPK, and mTOR signaling pathways for applications in healthspan longevity, regenerative medicine, performance optimization, and disease modulation. The technology has been licensed to Lionheart Health, Inc. for commercialization and clinical development.
The provisional patent application, invented by Howard J. Leonhardt, covers wearable, implantable, and external bioelectric stimulation systems designed to dynamically regulate major longevity-associated pathways involved in mitochondrial function, autophagy, stem cell preservation, tissue regeneration, muscle maintenance, metabolic optimization, cognitive performance, vascular function, and immune resilience.
The technology platform combines frequency-specific bioelectric stimulation with adaptive waveform control, AI-driven personalization, biomarker-guided optimization, and optional integration with regenerative biologics including peptides, stem cells, exosomes, hydrogels, gene therapies, red light therapy, PEMF, and neuromuscular stimulation systems.
“FOXO3, AMPK, and mTOR are among the most important master regulators of aging, regeneration, metabolism, and tissue preservation,” stated Howard J. Leonhardt, Executive Chairman and CEO of Leonhardt Ventures and Executive Chairman and Co-CEO of Lionheart Health. “Our goal is to develop non-invasive and implantable bioelectric systems capable of safely optimizing these pathways dynamically and potentially improving healthspan, resilience, regeneration, and quality of life.”
The patent pending application in process further expands the Leonhardt portfolio of bioelectric protein expression and regenerative medicine intellectual property.
Key Targeted Applications To Be Covered by the Patent Application
Longevity & Healthspan
- Healthy aging optimization
- Frailty reduction
- Biological age optimization
- Cellular resilience enhancement
- Mitochondrial optimization
- Autophagy enhancement
- Circadian rhythm synchronization
Muscle, Bone & Performance
- Sarcopenia reduction
- Muscle preservation during aging
- Athletic performance optimization
- Recovery enhancement
- Bone density support
- Osteoporosis applications
- Mobility and gait enhancement
Brain & Cognitive Health
- Cognitive performance enhancement
- Neuroprotection
- Memory support
- Mood optimization
- Brain regeneration support
- Neurodegenerative disease applications
Metabolic & Cardiovascular Applications
- Metabolic syndrome applications
- Glucose regulation support
- Weight management
- Cardiovascular support
- Vascular regeneration
- Blood pressure optimization
- Kidney protection and regeneration support
Regenerative Medicine Applications
- Stem cell enhancement
- Stem cell homing optimization
- Exosome enhancement
- Wound healing
- Organ regeneration
- Tissue engineering support
- Bioelectric-enhanced regenerative biologics
Aesthetic & Wellness Applications
- Skin rejuvenation
- Hair regeneration
- Sexual wellness
- Energy and vitality enhancement
- Wellness optimization programs
Platform Technologies Included
- Wearable stimulation systems
- Implantable stimulation systems
- AI-driven adaptive waveform systems
- Closed-loop biomarker feedback systems
- Whole-body stimulation suits
- Bioelectric-enhanced peptide delivery systems
- Circadian synchronized stimulation systems
- Combination regenerative therapy platforms
For additional information visit:
www.lionhearthealthstim.com
www.lionheartlongevity.com