Longevity Soluble Klotho Blood Test

Klotho is a protein that plays a significant role in the regulation of aging and age-related diseases. It is named after the Greek fate responsible for spinning the thread of life. The Klotho protein was first discovered in 1997 in mice, where mutations in the gene encoding Klotho led to a premature aging phenotype. Since then, it has been extensively studied in various organisms, including humans. There are two main forms of Klotho: membrane-bound Klotho (mKlotho) and soluble Klotho (sKlotho).

Soluble Klotho is found in the blood and cerebrospinal fluid and has been implicated in various physiological processes, including anti-aging effects, protection against oxidative stress, modulation of ion channels, and regulation of cell survival and proliferation.

Research shows that Klotho plays a role in promoting longevity and protecting against age-related diseases such as cardiovascular disease, neurodegenerative disorders, and cancer. Additionally, Klotho deficiency has been associated with accelerated aging and increased susceptibility to age-related diseases in animal models and humans.